In a  new study, researchers examined herbal supplements with immune-activating properties that could trigger or worsen autoimmune skin conditions, such as in people with cutaneous lupus erythematosus (CLE) or systemic lupus erythematosus (SLE). They identified 227 distinct herbal supplements that could trigger skin flares. Among these, 15 herbs had the strongest immune-activating effects across human, animal, and in-vitro studies. 

Researchers reviewed data from more than 11,800 studies, of which 469 met study inclusion criteria. The15 herbs with the most robust evidence for immunostimulatory effects included:  alfalfa, ashwagandha, astragalus, chlorella, echinacea, garlic, ginseng, green tea extract, Indian mulberry, liquorice, mistletoe, reishi mushroom, skullcap, spirulina and tinospora. These herbal supplements are frequently marketed for ‘immune support’ and were associated with inflammation-inducing mechanisms, including increased cytokine production and immune pathway activation.

More research is needed to understand the biological effects and risks of herbal supplements in people with autoimmune skin diseases. However, this study may help healthcare providers discuss the risks of particular herbal supplements with patients who have autoimmune skin conditions, such as CLE or SLE. Talk to your doctor before making any changes to your treatment. Learn more about lupus and the skin.

Read the study