NKX019-102 (Ntrust-1)
Study Title:
NKX019-102 (Ntrust-1), A Phase 1 Study of NKX019, a CD19 Chimeric Antigen Receptor Natural Killer (CAR NK) Cell Therapy, in Subjects with Autoimmune Disease
Sponsor Name:
Nkarta
Purpose of Study:
As many as half of all adults living with lupus have kidney disease related to their lupus.1 This condition, called lupus nephritis, can worsen over time and may lead to kidney failure.2 Studies like the Ntrust-1 study are designed to assess the safety and activity of a new investigational therapy.
The purpose of the Ntrust-1 study is to:
- See if NKX019 is safe to use and how well it is tolerated
- See if NKX019 can improve kidney function
- See if other medications like steroids can be stopped because lupus is controlled
- See how the body processes NKX019 by measuring the NKX019 levels in the blood.
1 https://www.niddk.nih.gov/health-information/kidney-disease/lupus-nephritis
2 https://www.kidney.org/kidney-topics/lupus-nephritis
Who can join this study?
You may be eligible to participate in this study if you:
- Are 18 to 65 years old
- Have been diagnosed with lupus nephritis
- Have received at least two prior therapies for lupus nephritis
You will also need to meet additional requirements. The study team will review these with you.
You can find more information about the Ntrust-1 study and see if you may be able to join by visiting Ntrust-1.com and taking a brief questionnaire.
You are not eligible to participate in this study if you:
- Have had prior or cell therapy, including mesenchymal, CAR-T or CAR-NK
- Are pregnant or breast feeding
- Have active liver disease
Study Type:
Phase 1
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. If you are a person living with lupus or a caregiver and you want to learn more about clinical trials and other research opportunities that may be right for you or your family member living with lupus, sign up for the Lupus Foundation of America’s Research Accelerated by You (RAY®) online patient and caregiver registry, if you have not already done so. Compensation is available.