Relationship between Systemic Lupus Erythematosus and Primary Biliary Cirrhosis
Systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) are both chronic autoimmune diseases. PBC primarily affects the liver and is characterized by inflammation or swelling of the bile ducts and scar tissue, which can lead to liver dysfunction and cancer. A recent study looked at overlapping cases of SLE and PBC and found that SLE and PBC were high-risk factors for each other as they have similar genetic bases.
The study used a randomization analysis to explore the potential causal relationship between SLE and PBC. The analysis showed that both SLE and PBC were high-risk factors for the occurrence and development of the other disease. Researchers identified nine hub genes (genes that interact with many other genes) that provide a potential mechanism and therapeutic target for people with overlapping cases of SLE and PBC.
More studies are needed to further investigate the overlap of the two diseases and identify potential therapeutic targets. Learn more about diseases that overlap with lupus.
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