Researchers Identify Potential New Genetic Biomarker for Systemic Lupus Erythematosus

A new study examined the RUNX3 gene in people with systemic lupus erythematosus (SLE) and discovered increased methylation levels (or chemical changes) of the gene in blood cells. RUNX3 gene levels could be used as a potential biomarker for diagnosing SLE.

Researchers analyzed and compared levels of the RUNX3 gene in 80 people with SLE and 77 healthy people. The chemical makeup of the proteins associated with the RUNX3 gene were significantly higher in people with SLE than healthy individuals. Additionally, people with SLE and kidney disease exhibited higher levels of RUNX3 chemical changes compared to those without renal involvement. A positive correlation between high levels of RUNX3 and creatinine (kidney waste product) concentration was also discovered, which suggests the functional disruption of the gene could contribute to the development of lupus nephritis.

Chemical levels of RUNX3 in blood cells may serve as a potential biomarker for SLE diagnosis, as well as kidney damage and overall disease activity. More research is needed to understand the chemical changes of the gene. Learn more about genes and lupus.