Racial Differences Found in the Microbiome in People with Systemic Lupus Erythematosus

A new study examined the relationship between race and the plasma microbiome, or gut matter, in people with lupus. Researchers discovered racial differences in the plasma and identified specific plasma microbiome differences associated with systemic lupus erythematosus (SLE) disease pathogenesis which may provide insights for future treatment. 

124 participants were recruited for the study, including 74 people with SLE (25 White; 49 Black/African-American) and 50 people without SLE (23 White; 27 Black/African-American). Researchers studied the movement of microbial products from the gut into the bloodstream of participants (called microbial translocation) and found increased levels of microbial products in the plasma of Black/African-American people with SLE compared to White people with SLE. When looking at the microbial diversity, researchers found Black/African-American and White people with SLE had different microbiome associations with distinct clinical characteristics. Black/African-American people with SLE had increased plasma levels of microbial translocation compared to White people with SLE, which suggests race may influence disruption in the gut. Additionally, Black people with SLE had higher SLEDAI scores (SLEDAI: Systemic Lupus Erythematosus Disease Activity Index; a tool used by physicians to assess disease activity in SLE), urinary protein levels, and increased anti-double DNA (dsDNA) antibody levels compared to White people with SLE. 

Black/African-American people often experience more severe lupus disease activity, but it is unknown exactly why that is. While more research is needed, this study provides interesting insight into how racial differences could play a role in SLE pathogenesis. Learn more about lupus and the digestive system.

Read the study