Genetic Predisposition and Long-Term Exposure to Air Pollution Associated with Increased Risk of Developing Systemic Lupus Erythematosus

A new, first-of-its-kind study looked at associations between air pollutants, genetic susceptibility and the risk of developing systemic lupus erythematosus (SLE). Researchers found that individuals with certain genetic predispositions and exposure to harmful air pollution were at greater risk of developing SLE. 

Using longitudinal data from 459,815 participants in the UK BioBank, the relationship between air pollution and SLE was examined by researchers. Of the participants, 399 have SLE and were more likely to be female and non-white. Additionally, the SLE participants were former or current smokers, not current drinkers, retired or unemployed, lower household income, and experienced higher concentrations of air pollution compared to the participants without SLE. 

Furthermore, specific pollutants including particulate matters (PM) 2.5 and 10, nitrogen dioxide (NO2), and nitrogen oxides (NOx) potentially increased risk of developing SLE after long-term exposure. Those with both high genetic risk and high pollution exposure had the highest SLE risk. The study concluded that air pollution and genetic predisposition together significantly raise the likelihood of developing SLE. 

While the exact cause of lupus remains unknown, this study suggests that both genetic and environmental factors may contribute to the onset of the disease. More research is needed to investigate the relationship between specific air pollutants and the development of SLE. Learn more about environmental triggers.

Read the study