Fatigue in People with Lupus Experiencing Neuropsychiatric Symptoms Linked to Emotional Health

According to new research, people with lupus experiencing neuropsychiatric (brain-related) symptoms are more likely to report extreme fatigue. While fatigue was not associated with disease activity, it was strongly linked to symptoms of anxiety and depression.

Scientists assessed 348 people with lupus experiencing neuropsychiatric symptoms, such as memory problems, headaches or mood-/coping-disorders, like anxiety or depression. In all, the majority (78%) of study subjects reported notably higher levels of fatigue compared to the general population. Interestingly, neither inflammation nor disease activity was associated with fatigue. However, 95% of people with likely anxiety disorder experienced fatigue compared to 66% of people without anxiety disorder. Similarly, 96% of those with probable depression reported fatigue compared to 61% of those without depression.

The latest findings suggest that treating mood-related symptoms may be a more effective way to manage fatigue in lupus than immunosuppressive (e.g., anti-inflammatory) treatment. Consult your physician before making any changes to your medication. Learn about strategies for managing fatigue.

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