Exploring the Role of Protein Receptor “Ptprz” in Lupus Nephritis and Future Treatments

In an important step toward better understanding and treating the lupus-related kidney disease, lupus nephritis (LN), Lupus Foundation of America (LFA) Gina M. Finzi Memorial Student Summer Fellowship (Finzi) award winner, Lin Chen, has identified a protein receptor that may promote the disease. The protein receptor known as “Ptprz” seems to play a role in kidney inflammation, scarring, and ultimately development of LN by drawing damaging inflammatory molecules to the kidneys.

These results show that Ptprz may play a critical role in inducing kidney inflammation and fibrosis, making it a potentially promising therapeutic target for LN moving forward. Up to 30% of people with LN develop end stage renal disease, which results in kidney failure, and finding new treatments to minimize kidney inflammation and damage is crucial.

Although Chen’s research supported by LFA’s Finzi award has ended, the research project will continue to move forward at Kelley Lab as Chen completes her undergraduate degree in Biology. “Working on this project has furthered my interest in pursuing lupus research in my medical career,” states Chen. Next, she plans to get more clinical experience, working directly with people with lupus and learning more about the sociological aspects of the disease.

Each year, the Finzi award grant program connects students with leading scientists in the lupus field to advance lupus research and contribute to future therapies, prevention strategies and educational programs. Learn more about Chen and her research efforts.