Thrombosis (coagulation or clotting of the blood) is a common blood disorder in lupus. Researchers examined for an association between C4d platelets and occurrence of thrombosis in people with systemic lupus erythematosus (SLE) and discovered a connection. Of the 149-person cohort, 16 had a history of thrombosis, venous thrombosis occurred in 10 patients, arterial thrombosis occurred in eight, and two people experienced both venous and arterials events. The lead author of the study was the Lupus Foundation of America 2018 Evelyn V. Hess Award winner, Michelle Petri, M.D., M.P.H. of Johns Hopkins University.

The research suggests that lupus disease activation (low C3), platelets (C4d) and anticoagulation pathways in lupus all interact to affect development of thrombosis. While more research is needed, clinicians could assess risk and individual markers to identify patients likely to benefit from interventions, including hydroxychloroquine therapy, to reduce risk of thrombosis. Learn about thrombosis in lupus.

This biomarker is included in Exagen’s AVISE SLE Monitor Test.

Read the study