In a new study, systemic lupus erythematosus (SLE) disease severity indicated by the presence of lupus nephritis, (LN, lupus-related kidney disease) and other SLE risk factors contributed to reduced bone mineral density (BMD) and an increased risk of osteoporosis. People with SLE are at higher risk of fractures and osteoporosis, and the impact of disease-related factors on bone health is unclear.

The data of 110 individuals with SLE who were either currently or previously treated with glucocorticoids were examined. Researchers looked at BMD and osteoporosis-related factors. They found that 41% of participants had osteoporosis, and 29% of the cohort had major osteoporotic fractures, plus 35% of participants had LN. Lower BMD was associated with LN (Class III/IV), higher C-reactive protein (CRP), U1-RNP antibodies, and longer disease duration. Overall, osteoporosis was associated with LN, older age, higher health assessment questionnaire scores, and complement factor 3 levels.

This study highlights the importance of administering 3D bone structure screenings, such as the Dual-energy X-ray Absorptiometry (DXA) screening, in people with SLE, particularly those with higher disease activity, CRP, LN and U1-RNP antibodies. The study also underscores a need for improved and effective screening strategies in lupus. Learn more about how lupus affects the bones.

Read the study