In a new study, women with lupus who took hydroxychloroquine (HCQ) throughout their pregnancy experienced more favorable outcomes than women who did not take the therapy. Women who took HCQ had a significantly lower rate of preterm births, less flares, and lower incidence of pre-eclampsia. Pre-eclampsia occurs when there is a problem with the placenta; a change in the mother’s immune response to fetal/placental tissue also may contribute to the development of pre-eclampsia.

The pregnancies of 145 women with lupus were examined before and throughout their pregnancy. The outcomes of women taking HCQ were compared to outcomes of those not taking HCQ. Each woman made the decision to take HCQ or not. The women who did not take HCQ saw higher frequency of risk factors, such as lupus nephritis, blood clots, slightly more hypertension and more severe disease activity.

Lupus pregnancies are considered high risk. If planning a pregnancy, consult with your doctor or rheumatologist for best outcomes. Learn about planning a pregnancy when you have lupus.

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