The researchers hoped to learn about the genetic contributions to lupus susceptibility and how this might relate to specific lupus-related phenotypes, such as the presence of specific autoantibodies.
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The researchers hoped to determine whether differences in genetic ancestry and/or specific genes contribute the decreased risk of developing lupus nephritis among individuals of European descent.
The researchers hoped to learn about the relationship between type I interferon and premature heart disease risk among people with lupus.
The researchers hoped to learn about the degree to which sex-specific genetic differences contribute to the susceptibility to developing lupus.
The researchers hoped to learn about the relationship between the presence of specific lupus susceptibility genes and the development of specific disease manifestations.
The researchers hoped to identify a set of microRNAs common to three different strains of mice that have been genetically modified in different ways to have lupus, making it more likely that something similar to these microRNAs might be found in substantial percentages of people.
Dr. William Stohl of the University of Southern California discusses the relationships among various parts of the immune system and their role in triggering lupus.
Dr. David Pisetsky of the Duke University Medical Center, discusses where lupus research may be headed in the coming years.
Dr. Gregg Silverman of the University of California, San Diego, discusses how the field of lupus genetics has evolved and where the field is headed in the next several years.
Dr. Gregg Silverman discusses B-cells and how they contribute to the development of lupus and offers insight on the future direction of lupus research.
Dr. David Pisetsky of Duke University Medical Center discusses the role of apoptosis (programmed cell death) and microparticles in triggering lupus.
Dr. John Harley, Director of Rheumatology at the Cincinnati Children's Hospital, discusses the genes investigators believe may play a role in the underlying cause of lupus.
Dr. Michael Ward, an investigator with the intramural research program for the National Institute of Arthritis and Musculoskeletal and Skin Diseases, reviews how biomarkers are used to diagnose lupus and monitor disease activity.
Dr. Lindsey Criswell of the University of California, San Francisco discusses advances in the search for genes believed responsible for lupus.
The researchers hoped to find out if DNA methylation is different between twins when one twin has lupus and the other does not.