Paul J. Utz, MD, Stanford University

"Proteomic Studies in Systemic Lupus Erythematosus"

2007 Novel Pilot Projects Program

This grant award was made possible by funds contributed through a trust created in memory of Stephen and Catherine Pida

Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease that can progressively damage multiple organs. The pathophysiology of SLE involves antibody formation against self-molecules, including those directed against RNA and DNA. By employing several mouse models of SLE, this proposal will test the hypothesis that the initiation and progression of autoantibody production and end organ disease in SLE requires interferon signaling through three different intracellular proteins called IFNAR-2, STAT-1, and IRF-9. The results can be rapidly translated to the clinic by identifying new targets for drug development, and by discovering novel biomarkers for SLE.