Mariana Kaplan, MD, University of Michigan Medical School
“Mechanisms of Abnormal Phenotype and Function of Bone Marrow Endothelial Progenitor Stem Cells”
2007 Adult Stem Cell Grant Award
These grant awards are made possible through support by the Cooper Family Foundation
Systemic lupus is associated with significant increases in premature heart attacks. We propose that an important factor implicated in heart disease in lupus is the abnormal function of stem cells that repair damaged blood vessels. This proposal will investigate the potential mechanisms by which abnormal vascular repair occurs in lupus and could contribute to designing treatments aimed at decreasing the risk of this potentially fatal complication.