Amy Kao, MD, MPH, University of Pittsburgh
"C4d on Circulating Cells and Renal Tissues as Markers of Lupus Nephritis"
2008 Novel Pilot Projects Program
This grant is provided by the Louis Berkowitz Family Foundation.
SLE is a systemic autoimmune disease characterized by variable clinical manifestations and disease courses. Accurate means for monitoring kidney disease severity and activity are in urgent need. We have recently developed a unique assay for measuring complement proteins on circulating cells of SLE patients. We will determine the use of this assay for severity and activity of kidney inflammation due to SLE. These studies will enhance our understanding of the mechanisms and lead to improved monitoring of activity and response to therapy of lupus kidney disease.
Video: Watch Dr. Kao speak about her research