The researchers hoped to identify a set of microRNAs common to three different strains of mice that have been genetically modified in different ways to have lupus, making it more likely that something similar to these microRNAs might be found in substantial percentages of people.
The researchers studied the relationship between anti-NR2A antibodies and different aspects of lupus, especially whether there might be a relationship between these antibodies and NPSLE in patients from Japan.
The researchers hoped to create an internationally agreed-upon definition of a lupus flare that would have practical applications for clinical trial designs.
The researchers hoped to learn about the role of IFNs and macrophages (white blood cells) in the development of experimental lupus nephritis.
Some people have antiphospholipid syndrome without other forms of lupus, called primary antiphospholipid syndrome (PAPS). The researchers hoped to learn whether people with systemic lupus or PAPS had different amounts of TNF-α and sIL-2R in their blood.
The researchers hoped to find out if DNA methylation is different between twins when one twin has lupus and the other does not.
The researchers wanted to find out if any proteins in the blood could be used to diagnose CNS lupus.