The researchers hoped to learn about the relationship between the presence of specific lupus susceptibility genes and the development of specific disease manifestations.
For years, researchers have investigated the possibility of inhibiting the actions of lupus-related autoantibodies to reduce the extent of organ damage. Further research in this area has the potential to facilitate the development of new therapies for people with lupus.
The researchers aimed to estimate the risk of breast, endometrial, and ovarian cancers in women with lupus relative to that for the general population.
The researchers hoped to identify a set of microRNAs common to three different strains of mice that have been genetically modified in different ways to have lupus, making it more likely that something similar to these microRNAs might be found in substantial percentages of people.
The researchers studied the relationship between anti-NR2A antibodies and different aspects of lupus, especially whether there might be a relationship between these antibodies and NPSLE in patients from Japan.
The researchers hoped to create an internationally agreed-upon definition of a lupus flare that would have practical applications for clinical trial designs.
The researchers hoped to learn about the role of IFNs and macrophages (white blood cells) in the development of experimental lupus nephritis.
Some people have antiphospholipid syndrome without other forms of lupus, called primary antiphospholipid syndrome (PAPS). The researchers hoped to learn whether people with systemic lupus or PAPS had different amounts of TNF-α and sIL-2R in their blood.