The researchers wanted to compare the effectiveness of mycophenolate mofetil (CellCept) with that of azathioprine to prevent kidney flares after the initial treatment for nephritis was successful.
The researchers hoped to learn about the safety and potential effectiveness of belimumab in the treatment of lupus.
The researchers hoped to learn whether cognitive behavioral thearpy could help people with lupus cope with stress, anxiety, and depression, all of which may co-occur with a chronic illness.
Steroids are frequently used to treat lupus because they are highly effective and work quickly. However, steroids have many serious side effects. How much of a risk this may pose for children with lupus or younger adults with lupus has not been well-studied.
The researchers hoped to learn whether mRNA in urine samples for the protein made by the FOXP3 gene could be related to lupus kidney disease activity or response to treatment.
This trial was the first stage of testing for rontalizumab, which is a new treatment that interferes with an inflammatory protein called "interferon-alpha."