Will anti-dsDNA antibody always be present even when lupus is well-controlled or quiet?
We tend to see the antibody increase with active disease and decrease with quiescent (inactive) disease, but sometimes it doesn't play by those rules. Sometimes the antibody goes away entirely. Sometimes it never goes away, and sometimes it goes away and comes back. However, lupus can still be present even if these antibodies are not detected. Usually while a person has active lupus, the antibody will not go away entirely. However, while rare, researchers have seen this happen, especially after very aggressive treatments. Learn more about anti-dsDNA and the laboratory tests for lupus.
Medically reviewed on December 23, 2013